Flumazenil, HOT Input Curve

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Flumazenil, HOT Input Curve

The Multiinjection, HOT model is used in combination with the tissue model for multi-injection studies with 11C-Flumazenil as described by Delforge et al. [1]. Please refer to the documentation of the implemented tissue model for a more detailed description.

It is assumed that the total plasma activity of the tracer  CPlasma(t) is loaded from the menu as illustrated below.  


Operational Model Curve

The input curve is then calculated by applying an exponential metabolite correction which considers the two injections of hot ligand at time T1 and T3:



Parameter Fitting

Note that although the corresponding parameters have a fit box, they should normally be used for entering pre-determined values of injection times and metabolite correction parameters. The default parameters of the for the bi-exponential metabolite correction (A1, T1, A2, B2) used in this model are from [1].


1.Delforge J, Pappata S, Millet P, Samson Y, Bendriem B, Jobert A, Crouzel C, Syrota A: Quantification of benzodiazepine receptors in human brain using PET, [11C]flumazenil, and a single-experiment protocol. J Cereb Blood Flow Metab 1995, 15(2):284-300. DOI